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KMID : 0377619630050060609
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Korean Jungang Medical Journal
1963 Volume.5 No. 6 p.609 ~ p.613
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A comparative study on the toxicities of Panax ginseng, Platycodon grandiflorun and Polygala tenuifolia-saponin.
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ûóÞÖä¿/Hong, Sa Ack
ì°é»óú/ÑÑðý³/ÑÑç²âª/ÑÑÔÔâ³/ì°ôÉûú/ì°ùöòÉ/Lee, Yong Chae/Kim, Jae Hoon/Kim Yung Soo/Kim, Dong Soo/Lee, Chul Hwha/Rhee Hang Jeen
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Abstract
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As a preliminary study on Panax ginseng, the saponin fraction of Panax ginseng, Platycodon grandiflorun and Polygala tenuifolia were extracted and purified to compare with toxicities in animals.
Gypsophila saponin was used as the standard. Following were the results;
1) In fish the toxicities of saponins less intense from Ginseng and Platycodon were, while those of Polygala and Gypsophila were remarkable.
2) Hemolytic action of Ginseng saponin in defibrinized blood of cows, guinea pigs rabbits and rats was weak, which, however, was increased in order of Platycodi, Gypsophila and Polygala.
3) LP5n in mouse were; 275¡¾52.0mg/kg. with Ginseng, 367-1-52.05mg/kg. with Paltycodi, 111.9¡¾23.0mg/kg. with Gypsophila and 31.05¡¾4.55mg/kg. with Polygala respectively.
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KEYWORD
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